Gender-specific capacity of insulin resistance proxies to predict functional decline in older adults.

Mariam El Assar, Javier Angulo, José Antonio Carnicero, Begoña Molina-Baena, Francisco José García-García, Patricia Sosa, Leocadio Rodríguez-Mañas

Fundación para la Investigación Biomédica del Hospital de Getafe, Getafe, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigación IdiPaz, Madrid, Spain.Fundación para la Investigación Biomédica del Hospital de Getafe, Getafe, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigación IdiPaz, Madrid, Spain. · pubmed

Paper

Abstract

Insulin resistance determined by Homeostasis Model of Insulin Resistance (HOMA-IR) has been associated with functional decline in non-diabetic older subjects. However, insulin is not routinely assessed. The study evaluated the predictive value of non-insulin-dependent IR surrogates on functional decline in non-diabetic older men and women.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the predictive value of insulin resistance proxies on functional decline in older adults, which is relevant to aging research as it addresses factors that may contribute to age-related decline in functionality. However, the study appears to focus on associations rather than interventions or mechanisms that could directly influence longevity or aging processes, limiting its impact to a solid but not groundbreaking contribution to the field.

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