Identification of key genes and signaling pathways based on transcriptomic studies of aerobic and resistance training interventions in sarcopenia in SAMP8 mice.
Abstract
We examined the effects of resistance and aerobic exercise on the gene expression and biometabolic processes of aging skeletal muscle in senescence-accelerated mouse/prone 8 mice, a model of sarcopenia, and compared them with senescence-accelerated mouse/resistant 1 mice acting as controls. We found that exercise improved muscle strength, endurance, fiber size, also modulated genes and pathways related to synaptic transmission, potassium transport, JAK-STAT signaling, and PI3K-Akt signaling. Our results suggested that BDNF, JAK2, RhoC, Myh6, Stat5a, Tnnc1, and other genes may mediate the beneficial effects of exercise on sarcopenia through these pathways.
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Research summary
The paper investigates the effects of exercise on gene expression and metabolic processes related to sarcopenia, which is a significant age-related condition. While it contributes to understanding how exercise may mitigate some effects of aging, it primarily focuses on symptom management rather than addressing the root causes of aging itself. Thus, while the findings are solid, their impact on the broader field of longevity research is limited.
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