Exercise and nutrition benefit skeletal muscle: From influence factor and intervention strategy to molecular mechanism.
Abstract
Sarcopenia is a progressive systemic skeletal muscle disease induced by various physiological and pathological factors, including aging, malnutrition, denervation, and cardiovascular diseases, manifesting as the decline of skeletal muscle mass and function. Both exercise and nutrition produce beneficial effects on skeletal muscle growth and are viewed as feasible strategies to prevent sarcopenia. Mechanisms involve regulating blood flow, oxidative stress, inflammation, apoptosis, protein synthesis and degradation, and satellite cell activation through exerkines and gut microbiomes. In this review, we summarized and discussed the latest progress and future development of the above mechanisms for providing a theoretical basis and ideas for the prevention and treatment of sarcopenia.
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Research summary
The paper addresses sarcopenia, a condition associated with aging, and discusses the roles of exercise and nutrition in mitigating its effects. While it provides a review of mechanisms and strategies for prevention and treatment, it does not delve into the root causes of aging or propose novel interventions that could significantly alter the aging process itself. Thus, while it contributes to the understanding of a specific age-related condition, its overall impact on the broader field of longevity research is limited.
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