Osteosarcopenia predicts greater risk of functional disability than sarcopenia: a longitudinal analysis of FraDySMex cohort study.

Oscar Rosas-Carrasco, Betty Manrique-Espinoza, Juan Carlos López-Alvarenga, Beatriz Mena-Montes, Isabel Omaña-Guzmán

Geriatric Assessment Center, Health Department, Iberoamerican University, Mexico City, Mexico. Electronic address: [email protected] Assessment Center, Health Department, Iberoamerican University, Mexico City, Mexico. Electronic address: [email protected]. · pubmed

Paper

Abstract

Aging involves significant changes in body composition, marked by declines in muscle mass and bone mineral density alongside an increase in fat mass. Sarcopenia is characterized by low strength and muscle mass, and osteosarcopenia is the coexistence of sarcopenia and osteopenia/osteoporosis. Physiologically, there is a crosstalk between muscle and bone tissues mediated by several pathways. Both, sarcopenia and osteosarcopenia, have been related with adverse outcomes such as functional disability. However, there is a lack of longitudinal studies. Therefore, this study aimed to assess whether sarcopenia and osteosarcopenia phenotypes increased the risk of functional disability in a longitudinal cohort of community-dwelling adults.

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Research summary

The paper addresses the relationship between sarcopenia and osteosarcopenia with functional disability in aging adults, which is relevant to understanding age-related decline in physical function. However, it primarily focuses on the symptoms and consequences of these conditions rather than addressing the root causes of aging or proposing interventions for lifespan extension. The findings contribute to the existing knowledge but do not represent a significant advancement in the field.

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