Arctium lappaL. polysaccharides alleviate oxidative stress and inflammation in the liver and kidney of aging mice by regulating intestinal homeostasis.

Xueyan Jia, Haoming Liu, Guoliang Yin, Wen Xiang, Haotian Zhao, Xuan Zhang, Xue Tang, Xiangrong Cheng, Chia-Feng Kuo, Chang Liu, Wei Wang, Naiyan Lu

School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. · pubmed

Paper

Abstract

Arctium lappa L. polysaccharide (ALP) is a prominent bioactive compound renowned for its multifaceted functional properties, including anti-inflammatory, antioxidant, antifibrotic, immunomodulatory, and pro-apoptotic effects. This study evaluated the aging-delaying effect of ALP and its mechanisms using a D-galactose (D-gal)-induced aging model. After an 8-week treatment, ALP significantly ameliorated D-gal-induced inflammation and oxidative stress in the liver, kidneys, and intestines. Notably, ALP administration led to a marked reduction of the pathogenic bacterium Desulfovibrio and a substantial increase in the beneficial bacterium Muribaculum. These microbial shifts were associated with upregulated expression of intestinal tight junction proteins and intestinal mucins, leading to enhanced intestinal barrier integrity. Consequently, the leakage of enterotoxins and inflammatory mediators was effectively reduced. The findings indicate that ALP alleviates tissue inflammation and oxidative stress, while also delaying aging in mice. This effect is achieved through the regulation of intestinal ecological homeostasis and the repair of the intestinal immune barrier.

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Research summary

The paper investigates the effects of Arctium lappa L. polysaccharides on oxidative stress and inflammation in aging mice, which aligns with longevity research by addressing mechanisms that may contribute to aging. However, while the findings are interesting and contribute to understanding the role of gut health in aging, the study primarily focuses on a specific compound's effects rather than providing a broader insight into aging mechanisms or significant lifespan extension. Thus, it represents a solid but limited contribution to the field.

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