The role of p21 in cellular senescence and aging-related diseases.

Jiayu Yan, Siyi Chen, Zimei Yi, Ruowen Zhao, Jiayu Zhu, Shuwen Ding, Junhua Wu

Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Research Institute of Stomatology & Stomatological Hospital and Dental School, Tongji University, Shanghai, China. · pubmed

Paper

Abstract

During the aging process or disease progression, normal cells and tissues in the body undergo various stresses, leading to cell damage and the need for repair, adaptation, apoptosis, or defense responses. Cellular senescence is a key player in this process, influencing the rate of aging and disease progression. It can be triggered by different stress factors, resulting in irreversible cell cycle arrest and functional decline. Senescent cells often show high expression of cell cycle factors such as p21 and p16, which are involved in cell cycle arrest. p16 has long been recognized as a significant marker of aging. Recent evidence suggests that p21

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Research summary

The paper discusses the role of p21 in cellular senescence, which is directly related to the mechanisms of aging and age-related diseases. While it addresses important aspects of cellular senescence, the focus appears to be more on the characterization of p21 rather than on innovative approaches to mitigate aging or its root causes. Thus, it contributes solid research but lacks significant implications for advancing the field of longevity research.

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