The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in aging mice.

Peng Chen, Lining Wu, Jiexin Lei, Fuchao Chen, Lihua Feng, Gang Liu, Benhong Zhou

Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei. Electronic address: [email protected] of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei. Electronic address: [email protected]. · pubmed

Paper

Abstract

The current study aimed to evaluate the preventive effects of urolithin C (Uro C), a gut microbial metabolite of ellagitannins on D-galactose (D-gal)-induced brain damage during the aging process and to elucidate the underlying mechanisms. In our study, the protective effect of Uro C on D-gal-induced BV2 microglia cell-mediated neuroinflammation damage in primary cortical neurons in vitro was confirmed. The results in an aging model in vivo induced by D-gal demonstrated that Uro C prevented D-gal-induced memory impairment, long-term potentiation (LTP) damage, and synaptic dysfunction through behavioral, electrophysiological, and histological examinations. Additionally, amyloidogenesis was observed in the central nervous system. The findings indicated that Uro C exhibited a preventive effect on the D-gal-induced elevation of β-amyloid (1-42 specific) (Aβ

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Research summary

The paper investigates the effects of urolithin C on cognitive impairment and neuroinflammation in aging mice, which aligns with longevity research by addressing mechanisms that may contribute to age-related cognitive decline. However, while the findings are interesting, they primarily focus on a specific compound's effects rather than addressing broader root causes of aging or lifespan extension. Thus, the impact is solid but limited in scope.

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