The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial design and methods.

Kristen M Beavers, Brianna R Wolle, Jamy D Ard, Daniel P Beavers, Olivia Biehl, Peter H Brubaker, Andrew J Burghardt, Christa T Calderone, Julio Carballido-Gamio, Jason Fanning, Wendy M Kohrt, Monica Love, Catherine M MacLean, Barbara J Nicklas, Joshua Stapleton, Christine M Swanson, Ashley A Weaver, Marcelina Worden, Sarah J Wherry

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: [email protected]. · pubmed

Paper

Abstract

Among older adults living with obesity, intentional weight loss (WL) improves prognosis of many comorbidities. However, concomitant decline in bone mineral density (BMD) limits overall benefit of WL by increasing osteoporotic fracture risk. Identification of intervention strategies to maximize body fat loss, while minimizing harm to the musculoskeletal system, is an important area of clinical research. The main objective of the Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial (NCT05764733) is to compare the independent and combined effects of a 12-month intervention of resistance training (RT) plus bone-loading exercises and bisphosphonate use on dietary WL-associated bone loss among 308 older (≥60 years) adults living with an indication for WL and bisphosphonate use.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the important issue of bone health in older adults undergoing weight loss, which is a significant concern in the context of aging and longevity. However, it primarily focuses on treatment strategies rather than addressing the root causes of aging or lifespan extension. The findings may contribute to better management of age-related conditions but do not represent a major breakthrough in the field of longevity research.

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