Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial.

Dafna Pachter, Alon Kaplan, Gal Tsaban, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gidon Levakov, Moti Salti, Yoram Yovell, Sebastian Huhn, Frauke Beyer, Veronica Witte, Peter Kovacs, Martin von Bergen, Uta Ceglarek, Matthias Blüher, Michael Stumvoll, Frank B Hu, Meir J Stampfer, Alon Friedman, Ilan Shelef, Galia Avidan, Iris Shai

Faculty of Health Sciences, The Health & Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.Faculty of Health Sciences, The Health & Nutrition Innovative International Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. · pubmed

Paper

Abstract

We recently reported that Mediterranean (MED) and green-MED diets significantly attenuated age-related brain atrophy by ∼50% within 18 mo.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of dietary interventions (Mediterranean and green-Mediterranean diets) on brain health, specifically focusing on neuroprotection and brain atrophy, which are relevant to aging and longevity. While the findings contribute to our understanding of how diet can influence brain aging, the impact is somewhat limited as it primarily addresses dietary effects rather than fundamental mechanisms of aging or lifespan extension. Thus, it represents solid research but does not significantly advance the field.

Author of this paper? Send a correction.