Senoinflammation as the underlying mechanism of aging and its modulation by calorie restriction.

Sang Gyun Noh, Hyun Woo Kim, Seungwoo Kim, Ki Wung Chung, Young-Suk Jung, Jeong-Hyun Yoon, Byung Pal Yu, Jaewon Lee, Hae Young Chung

Research Institute for Drug Development, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea.Research Institute for Drug Development, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea. · pubmed

Paper

Abstract

Senoinflammation is characterized by an unresolved low-grade inflammatory process that affects multiple organs and systemic functions. This review begins with a brief overview of the fundamental concepts and frameworks of senoinflammation. It is widely involved in the aging of various organs and ultimately leads to progressive systemic degeneration. Senoinflammation underlying age-related inflammation, is causally related to metabolic dysregulation and the formation of senescence-associated secretory phenotype (SASP) during aging and age-related diseases. This review discusses the biochemical evidence and molecular biology data supporting the concept of senoinflammation and its regulatory processes, highlighting the anti-aging and anti-inflammatory effects of calorie restriction (CR). Experimental data from CR studies demonstrated effective suppression of various pro-inflammatory cytokines and chemokines, lipid accumulation, and SASP during aging. In conclusion, senoinflammation represents the basic mechanism that creates a microenvironment conducive to aging and age-related diseases. Furthermore, it serves as a potential therapeutic target for mitigating aging and age-related diseases.

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Research summary

The paper addresses senoinflammation as a fundamental mechanism of aging and discusses its modulation through calorie restriction, which is directly related to the root causes of aging and age-related diseases. While it provides a solid overview and discusses biochemical evidence, the findings appear to be more of a synthesis of existing knowledge rather than presenting novel experimental data or groundbreaking insights. Thus, it contributes to the field but does not significantly advance it.

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