Targeting senescent cells in atherosclerosis: Pathways to novel therapies.
Abstract
Targeting senescent cells has recently emerged as a promising strategy for treating age-related diseases, such as atherosclerosis, which significantly contributes to global cardiovascular morbidity and mortality. This review elucidates the role of senescent cells in the development of atherosclerosis, including persistently damaging DNA, inducing oxidative stress and secreting pro-inflammatory factors known as the senescence-associated secretory phenotype. Therapeutic approaches targeting senescent cells to mitigate atherosclerosis are summarized in this review, which include the development of senotherapeutics and immunotherapies. These therapies are designed to either remove these cells or suppress their deleterious effects. These emerging therapies hold potential to decelerate or even alleviate the progression of AS, paving the way for new avenues in cardiovascular research and treatment.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses targeting senescent cells, which are implicated in the aging process and age-related diseases like atherosclerosis. By focusing on the underlying mechanisms of cellular senescence and its role in disease progression, the research aligns with longevity research goals. However, while it presents solid insights and therapeutic approaches, it does not introduce groundbreaking findings or novel concepts that would significantly advance the field, thus earning a moderate impact score.
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