Photobiomodulation ameliorates ovarian aging by alleviating oxidative stress and inflammation damage and improving mitochondrial function.

Yu He, Rongan Ye, Yinbo Peng, Qing Pei, Lei Wu, Caixia Wang, Wei Ni, Ming Li, Yiqiu Zhang, Min Yao

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. · pubmed

Paper

Abstract

Ovarian aging is a serious clinical concern. Few safe and effective methods are currently available to improve ovarian functions. Photobiomodulation (PBM) is a safe and noninvasive physical therapy that can modulate a series of biological processes. Recently, several studies have noted its potential to improve the function of ovary and reproductive cells. However, the effects of PBM treatment on natural ovarian aging remain unclear. In this study, we used a naturally reproductive aging mouse model to observe the effect of PBM on ovarian function. Young and aged female ICR mice were treated with or without PBM for 2 months. PBM was performed using a semiconductor InGaAlP laser emitting at 650 nm (80 mW, 6.7 mW/cm

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Research summary

The paper addresses ovarian aging and explores a potential intervention (photobiomodulation) that may alleviate some of the biological processes associated with aging, such as oxidative stress and inflammation. While it contributes to understanding a non-invasive approach to improve ovarian function, the findings are likely to be incremental rather than transformative for the field of longevity research. The focus on a specific treatment in a mouse model does not significantly advance the broader understanding of aging mechanisms or lifespan extension.

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