Chronic intermittent hypoxia triggers cardiac fibrosis: Role of epididymal white adipose tissue senescent remodeling?

Suzain Naushad, Jonathan Gaucher, Zaineb Mezdari, Maximin Détrait, Elise Belaidi, Yanyan Zhang, Guillaume Vial, Sophie Bouyon, Gabor Czibik, Maria Pini, Sahar Aldekwer, Hao Liang, Véronique Pelloux, Judith Aron-Wisnewsky, Renaud Tamisier, Jean-Louis Pépin, Geneviève Derumeaux, Daigo Sawaki, Claire Arnaud

Université Paris Est Créteil, INSERM U955, Créteil, France. · pubmed

Paper

Abstract

Obstructive sleep apnea (OSA) is a growing health problem affecting nearly 1 billion people worldwide. The landmark feature of OSA is chronic intermittent hypoxia (CIH), accounting for multiple organ damage, including heart disease. CIH profoundly alters both visceral white adipose tissue (WAT) and heart structure and function, but little is known regarding inter-organ interaction in the context of CIH. We recently showed that visceral WAT senescence drives myocardial alterations in aged mice without CIH. Here, we aimed at investigating whether CIH induces a premature visceral WAT senescent phenotype, triggering subsequent cardiac remodeling.

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Research summary

The paper investigates the effects of chronic intermittent hypoxia on visceral white adipose tissue and its potential role in cardiac remodeling, which relates to aging and age-related diseases. However, it primarily focuses on the pathological consequences of a specific condition (OSA) rather than addressing the root causes of aging or proposing mechanisms for lifespan extension. The findings may contribute to understanding the interplay between obesity, hypoxia, and heart disease, but they do not present a significant advancement in the field of longevity research. Thus, while relevant, the impact is limited.

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