L-carnitine cause to increase cell proliferation of C-Kit

Behnaz Valipour, Ezzatollah Fathi, Raheleh Farahzadi, Elahe Naderali, Hamed Behniafar

Department of Basic Sciences and Health, Sarab Faculty of Medical Sciences, Sarab, East Azerbaijan, Iran.Department of Basic Sciences and Health, Sarab Faculty of Medical Sciences, Sarab, East Azerbaijan, Iran. · pubmed

Paper

Abstract

Stem cell-based therapy has emerged as an attractive approach for regenerative medicine. Poor survival and maintenance of the cells used in regenerative medicine are considered as serious barriers to enhance the efficacy of the cell therapy. Using some antioxidants has been reported to prevent the aging of stem cells, and finding effective factors to reduce the senescence of these cells has impressive potential in cell therapy. The PI3K pathway adversely regulates the transcription factors known as FOXO, which are thought to have an inhibitory influence on cell proliferation. By downregulating FOXO and other targets, PI3K signaling controls the growth of cells. For this reason, the aim of the present study is to investigate the effect of L-carnitine (LC) as antioxidant on the cell proliferation and the protein expression of PI3K and FOXO.

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Research summary

The paper investigates the effects of L-carnitine on cell proliferation and its role in the PI3K pathway, which is relevant to understanding mechanisms that could potentially influence stem cell aging and senescence. However, the study appears to focus more on cellular mechanisms rather than directly addressing the root causes of aging or longevity. The findings may contribute to the field of regenerative medicine but do not present a significant breakthrough or transformative insights into longevity research.

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