Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion.

Satoru Meguro, Yoshikazu Johmura, Teh-Wei Wang, Satoshi Kawakami, Shota Tanimoto, Satotaka Omori, Yuki T Okamura, Seiji Hoshi, Emina Kayama, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Yoshiyuki Kojima, Makoto Nakanishi

Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. · pubmed

Paper

Abstract

Aging is a major risk factor for cancer, but the precise mechanism by which aging promotes carcinogenesis remains largely unknown. Here, using genetically modified mouse models, we show that p16

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the role of senescent fibroblasts in the aged bladder and their contribution to a tumor-permissive environment, which touches on mechanisms of aging and cancer. However, it primarily focuses on cancer promotion rather than addressing the root causes of aging or lifespan extension. The findings may contribute to understanding age-related cancer mechanisms but do not significantly advance the field of longevity research. Thus, the impact is limited.

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