Exploring the potential of epigenetic clocks in aging research.
Abstract
The process of aging is a notable risk factor for numerous age-related illnesses. Hence, a reliable technique for evaluating biological age or the pace of aging is crucial for understanding the aging process and its influence on the progression of disease. Epigenetic alterations are recognized as a prominent biomarker of aging, and epigenetic clocks formulated on this basis have been shown to provide precise estimations of chronological age. Extensive research has validated the effectiveness of epigenetic clocks in determining aging rates, identifying risk factors for aging, evaluating the impact of anti-aging interventions, and predicting the emergence of age-related diseases. This review provides a detailed overview of the theoretical principles underlying the development of epigenetic clocks and their utility in aging research. Furthermore, it explores the existing obstacles and possibilities linked to epigenetic clocks and proposes potential avenues for future studies in this field.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses the use of epigenetic clocks as biomarkers of aging, which is directly related to understanding the biological processes of aging and their implications for age-related diseases. While it provides a solid overview of the theoretical principles and potential applications of epigenetic clocks, the review nature of the paper suggests that it may not present groundbreaking new findings but rather summarizes existing knowledge. Thus, it has a limited impact on advancing the field significantly.
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