Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice.

Wilbert P Vermeij, Khalid Alyodawi, Ivar van Galen, Jennie L von der Heide, María B Birkisdóttir, Lisanne J Van't Sant, Rutger A Ozinga, Daphne S J Komninos, Kimberly Smit, Yvonne M A Rijksen, Renata M C Brandt, Sander Barnhoorn, Dick Jaarsma, Sathivel Vaiyapuri, Olli Ritvos, Tobias B Huber, Oliver Kretz, Ketan Patel

Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. · pubmed

Paper

Abstract

Ageing is a complex multifactorial process, impacting all organs and tissues, with DNA damage accumulation serving as a common underlying cause. To decelerate ageing, various strategies have been applied to model organisms and evaluated for health and lifespan benefits. Dietary restriction (DR, also known as caloric restriction) is a well-established long-term intervention recognized for its universal anti-ageing effects. DR temporarily suppresses growth, and when applied to progeroid DNA repair-deficient mice doubles lifespan with systemic health benefits. Counterintuitively, attenuation of myostatin/activin signalling by soluble activin receptor (sActRIIB), boosts the growth of muscle and, in these animals, prevents muscle wasting, improves kidney functioning, and compresses morbidity.

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Research summary

The paper addresses the root causes of aging by exploring the effects of dietary restriction and muscle growth promotion in a model of progeroid mice with DNA repair deficiencies. It presents findings that could contribute to understanding mechanisms of aging and potential interventions. However, while the research is solid, it appears to be an incremental advance rather than a groundbreaking discovery, limiting its overall impact on the field of longevity research.

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