Heterogeneous redox responses in NHDF cells primed to enhance mitochondrial bioenergetics.
Abstract
Aging and lifestyle-related diseases, such as cardiovascular diseases, diabetes, cancer, and neurodegenerative disorders, are major global health challenges. These conditions are often linked to redox imbalances, where cells fail to regulate reactive redox species (RRS), leading to oxidative stress and cellular damage. Although antioxidants are known to neutralize harmful RRS, their clinical efficacy remains inconsistent. One reason for this inconsistency is the inadequacy of current in vitro models to accurately mimic in vivo redox conditions. This study addresses the gap in understanding the heterogeneity of redox responses in cells by using metabolically primed human dermal fibroblasts (NHDF), a model relevant for precision mitochondrial medicine. We investigated how metabolic priming, which enhances mitochondrial bioenergetics, influences redox responses to oxidative stress induced by hydrogen peroxide (H
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper investigates the redox responses in human dermal fibroblasts and their relation to mitochondrial bioenergetics, which is relevant to understanding cellular mechanisms that could influence aging and age-related diseases. However, the focus on oxidative stress and antioxidant responses, while important, does not directly address the root causes of aging or propose significant interventions for lifespan extension. The findings may contribute to the field but are more incremental than groundbreaking.
Author of this paper? Send a correction.