Aging delays the suppression of lipolysis and fatty acid oxidation in the postprandial period.

Adam D Osmond, Robert G Leija, Jose A Arevalo, Casey C Curl, Justin J Duong, Melvin J Huie, Umesh Masharani, George A Brooks

Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States. · pubmed

Paper

Abstract

Plasma glycerol and free fatty acid concentrations decrease following oral glucose consumption, but changes in the rate of lipolysis during an oral glucose tolerance test (OGTT) have not been documented in conjunction with changes in fatty acid (FA) oxidation or reesterification rates in healthy individuals. After a 12-h overnight fast, 15 young (21-35 yr; 7 men and 8 women) and 14 older (60-80 yr; 7 men and 7 women) participants had the forearm vein catheterized for primed continuous infusion of [1,1,2,3,3-

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Research summary

The paper investigates the physiological changes in lipolysis and fatty acid oxidation in relation to aging, which can provide insights into metabolic processes that may influence longevity. However, the study appears to focus on specific metabolic responses rather than addressing broader mechanisms of aging or interventions that could extend lifespan. Thus, while it contributes to our understanding of age-related metabolic changes, its overall impact on the field of longevity research is limited.

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