An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases.

Yudai Xu, Zijian Wang, Shumin Li, Jun Su, Lijuan Gao, Junwen Ou, Zhanyi Lin, Oscar Junhong Luo, Chanchan Xiao, Guobing Chen

Department of Microbiology and Immunology, School of Medicine; Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China.Department of Microbiology and Immunology, School of Medicine; Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China. · pubmed

Paper

Abstract

T cells play a critical and irreplaceable role in maintaining overall health. However, their functions undergo alterations as individuals age. It is of utmost importance to comprehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies. In this review, we have thoroughly examined the existing studies on the characteristics of immune organ aging. Furthermore, we elucidated the changes and potential mechanisms that occur in T cells during the aging process. Additionally, we have discussed the latest research advancements pertaining to T-cell aging-related diseases. These findings provide a fresh perspective for the study of T cells in the context of aging.

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Research summary

The paper claims that understanding T-cell aging is crucial for insights into aging-related diseases and therapeutic strategies. This research is relevant as it addresses the mechanisms of immune organ aging, which is a fundamental aspect of the aging process and its impact on health.

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