The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age.
Abstract
The Y chromosome has long been considered to be a "genetic wasteland" harboring only few genes essentially involved in male sex development and spermatogenesis. However, the discovery of mosaic loss of the Y chromosome (mLOY) in older men has led to revisiting of the potential impact of the Y chromosome on health and the pathophysiological processes of multiple diseases such as cancer, Alzheimer's disease and cardiovascular disease. Hence, developing more sensitive techniques for the detection of mLOY has become an emergent concern. In this article, we present a comprehensive review of the literature regarding mLOY. Additionally, we discuss the emerging discoveries concerning mLOY as well as the underlying mechanisms promoting disease in men of advanced age.
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Research summary
The paper discusses the mosaic loss of the Y chromosome (mLOY) and its potential implications for health in older men, particularly in relation to diseases associated with aging. While it touches on important topics related to aging and disease mechanisms, it primarily focuses on the correlation between mLOY and age-related diseases rather than addressing the root causes of aging or proposing solutions for lifespan extension. Therefore, while it is relevant to longevity research, its impact is limited as it does not present groundbreaking findings or significant advancements in the field.
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