Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat with liver fibrosis via inhibiting p53-related senescence and NLRP3-related inflammation.

Jinying Liu, Xiaoli Ma, Wang Guo, Bingxin Lu, Yanqin Yue, Xingyuan Yang, Rui Wang, Caihong Wu, Bingyong Zhang, Xiuling Li, Xiaoying Luo

Department of Gastroenterology, Henan Provincial People's Hospital, Henan University People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, China; Microbiome Laboratory, Henan Provincial People's Hospital, Henan University People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, China; Jiaozuo Coal Industry (Group) Co. Ltd. Central Hospital, Jiaozuo 410800, China. Electronic address: [email protected] of Gastroenterology, Henan Provincial People's Hospital, Henan University People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, China; Microbiome Laboratory, Henan Provincial People's Hospital, Henan University People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, China; Jiaozuo Coal Industry (Group) Co. Ltd. Central Hospital, Jiaozuo 410800, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Senescence represents a major risk factor promoting liver fibrosis progression. Sirtuin 1 (SIRT1), an essential regulator of cellular senescence, may be involved in developing liver fibrosis. However, the role and mechanism of SIRT1 in liver fibrosis development were largely unknown. We constructed the liver fibrosis in aged rats induced by carbon tetrachloride (CCl

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Research summary

The paper investigates the role of Sirtuin 1 (SIRT1) in liver fibrosis, focusing on mechanisms related to cellular senescence and inflammation, which are relevant to the aging process. However, while it addresses a significant aspect of age-related disease, the findings appear to be more incremental rather than groundbreaking, as they primarily explore the effects of SIRT1 without offering novel insights that could lead to substantial advancements in longevity research.

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