Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.

Huaming Xi, Wenjing Shan, Minghui Li, Ziqian Wang, Yuan Li

Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, People's Republic of China. · pubmed

Paper

Abstract

Reproductive aging can adversely affect male fertility and the health of offspring. The aging process is accompanied by impaired autophagy. Recent studies have shown that Trehalose plays an important role in the prevention of various diseases by regulating autophagy. However, the roles of Trehalose in testicular aging and reproductive decline remain to be clarified.

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Research summary

Trehalose may improve testicular health by enhancing autophagy and mitochondrial function. The study addresses mechanisms related to reproductive aging, which is a critical aspect of the broader aging process.

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