G Protein-Coupled Receptors in Skin Aging.

Suet Ting Cheung, Yelim Do, Eunah Kim, Antonella Rella, Earl Goyarts, Nadine Pernodet, Yung Hou Wong

The Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; The Biotechnology Research Institute, The Hong Kong University of Science and Technology, Hong Kong, China. · pubmed

Paper

Abstract

Skin aging is a complex biological process affected by a plethora of intrinsic and extrinsic factors that alter cutaneous functions through the modulations of signaling pathways and responses. Expressed in various cell types and skin tissue layers, G protein-coupled receptors (GPCRs) play a vital role in regulating skin aging. We have cataloged 156 GPCRs expressed in the skin and reviewed their roles in skin aging, such as pigmentation, loss of elasticity, wrinkles, rough texture, and aging-associated skin disorders. By exploring the GPCRs found in the skin, it may be possible to develop new treatment regimens for aging-associated skin conditions using GPCR ligands.

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Research summary

The paper claims that understanding the roles of GPCRs in skin aging could lead to new treatment regimens for aging-associated skin conditions. The focus on GPCRs in the context of skin aging addresses mechanisms that could contribute to the broader understanding of aging processes.

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