Granzyme B in aging and age-related pathologies.

Katlyn C Richardson, Karen Jung, Joanne A Matsubara, Jonathan C Choy, David J Granville

International Collaboration On Repair Discoveries (ICORD) Centre, Department of Pathology and Laboratory Medicine, British Columbia Professional Firefighters' Burn and Wound Healing Laboratory, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.International Collaboration On Repair Discoveries (ICORD) Centre, Department of Pathology and Laboratory Medicine, British Columbia Professional Firefighters' Burn and Wound Healing Laboratory, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada. · pubmed

Paper

Abstract

Aging is a major risk factor for pathologies that manifest later in life. Much attention is devoted towards elucidating how prolonged environmental exposures and inflammation promote biological (accelerated) tissue aging. Granzymes, a family of serine proteases, are increasingly recognized for their emerging roles in biological aging and disease. Widely recognized as intracellular mediators of cell death, granzymes, particularly granzyme B (GzmB), also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and impaired healing. Consequently, this has prompted the field to reconsider how GzmB regulation, accumulation, and proteolysis impact health and disease with age. While GzmB is observed in numerous age-related conditions, the current review focuses on mechanistic studies where proof-of-concept has been forwarded.

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Research summary

The paper discusses granzyme B's role in aging and age-related pathologies, focusing on its accumulation and effects on chronic tissue injury and inflammation. While it addresses mechanisms related to aging, it does not propose solutions to the root causes of aging or lifespan extension. The findings contribute to understanding the role of granzymes in aging but represent a solid yet limited impact in the broader context of longevity research.

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