Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise.
Abstract
Enigmatic sarcopenic obesity is still a challenge for science and adds to the global public health burden. The progressive accumulation of body fat combined with a dysfunctional skeletal muscle structure and composition, oxidative stress, mitochondrial dysfunction, and anabolic resistance, among other aggravating factors, together represent the seriousness and complexity of treating the metabolic disorder of sarcobesity in aging. For this reason, further studies are needed that encourage the support of therapeutic management. It is along these lines that we direct the reader to therapeutic approaches that demonstrate important, but still obscure, outcomes in the physiological conditions of sarcobesity, such as the role of taurine in modulating inflammatory and antioxidant mechanisms in muscle and adipose tissue, as well as the management of gut microbiota, able to systemically re-establish the structure and function of the gut-muscle axis, in addition to the merits of physical exercise as an instrument to improve muscular health and lifestyle quality.
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Research summary
The paper addresses sarcopenic obesity, a condition that combines aspects of aging and metabolic dysfunction, which is relevant to longevity research. It discusses potential therapeutic approaches involving taurine supplementation, gut microbiota management, and exercise, which could contribute to healthier aging. However, the findings appear to be incremental and do not present groundbreaking insights or solutions that significantly advance the understanding of aging mechanisms or lifespan extension. Thus, while it is relevant, its impact is limited.
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