Transcriptome analyses reveal key features of mouse seminal vesicle during aging.

Peng Luo, Haibin Guo, Baoning Liu, Zhiqiang Zhang, Yun Xie, Jiahui Yao, Xiangping Li, Jun Bian, Jintao Zhuang, Bin Ouyang, Jinhua Wu

Reproductive Medicine Center, The Key Laboratory for Reproductive Medicine of Guangdong Province, The First Affiliated Hospital, SunYat-sen University, Guangzhou, China.Reproductive Medicine Center, The Key Laboratory for Reproductive Medicine of Guangdong Province, The First Affiliated Hospital, SunYat-sen University, Guangzhou, China. · pubmed

Paper

Abstract

Despite the significant morphological changes that occur in the seminal vesicles with aging, the transcriptomic characteristics remain largely unexplored. To address this, we performed bulk RNA sequencing on seminal vesicle samples from mice aged 3, 13, and 21 months to uncover transcriptomic alterations. Our findings reveal that aged seminal vesicles display cystic dilatation, epithelial hypoplasia, disordered muscle layers, fibrosis, and reduced proliferation capability. A comparison between 3-month-old and 21-month-old mice indicated that leukocyte-mediated immunity and leukocyte migration were the most significantly upregulated biological processes among differentially expressed genes (DEGs). Notably, several DEGs associated with "leukocyte migration," such as

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Research summary

The paper investigates transcriptomic changes in mouse seminal vesicles with aging, which is relevant to understanding biological processes associated with aging. However, the focus on morphological changes and immune response does not directly address the root causes of aging or lifespan extension. The findings contribute to the field but are more of a solid research effort rather than a significant advancement.

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