Functional Food Mixture Extricates D-Galactose-Induced Skeletal Muscle Impairment in Rats.
Abstract
Aging-related muscle atrophy/sarcopenia is the most common type of muscle impairment that affects the quality of life. In the current study, we examined the effect of a functional food mixture of amla, turmeric, black pepper, cinnamon, and ginger on D-galactose-induced muscle alterations in rats. Wistar rats were randomly divided into three groups: Control (C), D-galactose (G), and D-galactose + functional food mixture intervention (G + I). Rats in group-G and -G + I were injected with D-galactose (300 mg/kg/day) for 90 days. After 3 months of the experimental period, the rats were sacrificed to collect gastrocnemius muscle. Group-G rats showed elevated levels of inflammatory cytokines (TNFα and NF-kB), atrogenes (atrogin-1 and MuRF1), decreased insulin/IGF1 signaling (decreased AKT phosphorylation), altered mitochondrial dynamics (increased fission and decreased fusion proteins), increased apoptotic mediators (Bax/Bcl-2, and caspase-3), and decreased muscle cell cross-sectional area when compared with group-C (
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Research summary
The paper investigates the effects of a functional food mixture on muscle impairment induced by D-galactose in rats, which is relevant to aging-related muscle atrophy. However, the study primarily focuses on symptomatic treatment rather than addressing the root causes of aging or lifespan extension. While it contributes to understanding dietary interventions for muscle health in aging, its overall impact on the field of longevity research is limited.
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