Causal Associations of Cognitive Reserve and Hierarchical Aging-Related Outcomes: A Two-Sample Mendelian Randomization Study.
Abstract
Two-sample Mendelian randomization methods were used to explore the causal effects of cognitive reserve proxies, such as educational attainment, occupational attainment, and physical activity (PA), on biological (leukocyte telomere length), phenotypic (sarcopenia-related features), and functional (frailty index and cognitive performance) aging levels.
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Research summary
The paper investigates causal associations between cognitive reserve and various aging-related outcomes, utilizing Mendelian randomization to explore potential mechanisms that could influence longevity. While it contributes to understanding factors that may mitigate aging effects, the findings are more incremental rather than groundbreaking, limiting its overall impact on the field of longevity research.
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