Nutrient sensing of mTORC1 signaling in cancer and aging.
Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) is indispensable for preserving cellular and organismal homeostasis by balancing the anabolic and catabolic processes in response to various environmental cues, such as nutrients, growth factors, energy status, oxygen levels, and stress. Dysregulation of mTORC1 signaling is associated with the progression of many types of human disorders including cancer, age-related diseases, neurodegenerative disorders, and metabolic diseases. The way mTORC1 senses various upstream signals and converts them into specific downstream responses remains a crucial question with significant impacts for our perception of the related physiological and pathological process. In this review, we discuss the recent molecular and functional insights into the nutrient sensing of the mTORC1 signaling pathway, along with the emerging role of deregulating nutrient-mTORC1 signaling in cancer and age-related disorders.
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Research summary
The paper discusses the mTORC1 signaling pathway, which is crucial for understanding cellular processes related to aging and age-related diseases. While it addresses the role of mTORC1 in cancer and age-related disorders, it primarily focuses on the signaling mechanisms rather than directly targeting the root causes of aging or lifespan extension. Thus, it provides solid insights but has limited impact on advancing the field of longevity research.
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