Oxidative phosphorylation and fatty acid oxidation in slow-aging mice.

Ahmed M Elmansi, Richard A Miller

Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA; University of Michigan Geriatrics Center, Ann Arbor, MI, USA.Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA; University of Michigan Geriatrics Center, Ann Arbor, MI, USA. · pubmed

Paper

Abstract

Oxidative metabolism declines with aging in humans leading to multiple metabolic ailments and subsequent inflammation. In mice, there is evidence of age-related suppression of fatty acid oxidation and oxidative phosphorylation in the liver, heart, and muscles. Many interventions that extend healthy lifespan of mice have been developed, including genetic, pharmacological, and dietary interventions. In this article, we review the literature on oxidative metabolism changes in response to those interventions. We also discuss the molecular pathways that mediate those changes, and their potential as targets for future longevity interventions.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the decline of oxidative metabolism with aging and discusses interventions that may extend healthy lifespan in mice, which is directly related to longevity research. It reviews molecular pathways that could be targeted for future interventions, indicating a solid contribution to understanding mechanisms of aging. However, the impact is limited as it primarily synthesizes existing literature rather than presenting novel experimental findings or breakthroughs.

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