BV2-derived extracellular vesicles modulate microglia inflammatory profile, neuronal plasticity, and behavioural performances in late adult mice.

Arianna Rinaldi, Marta Balietti, Elisa Principi, Mariassunta De Luca, Eleonora De Felice, Francesca Michela Narcisi, Laura Vilardo, Maria Rosito, Roberto Piacentini, Giuseppina D'Alessandro, Igea D'Agnano, Laura Maggi, Fiorenzo Conti, Cristina Limatola, Myriam Catalano

Department of Physiology and Pharmacology, Sapienza University, Rome, Italy. · pubmed

Paper

Abstract

During aging, both the brain and the immune system undergo a progressive impairment of physiological functions. Microglia, the immunocompetent cells of the central nervous system, shift towards a chronic mild inflammatory state that impacts brain homeostasis. Extracellular vesicles (EVs) released by microglia transport packages of molecular information that mirror the inflammatory status of donor cells and modulate the inflammatory phenotype of recipient microglia and other cell types.

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Research summary

The paper investigates the role of microglia and their extracellular vesicles in modulating inflammation and neuronal plasticity in aging mice, which is relevant to understanding the mechanisms of aging and potential interventions. However, the findings appear to be more focused on the inflammatory response rather than addressing the root causes of aging or lifespan extension. Thus, while it contributes to the field, its impact is limited and more incremental than groundbreaking.

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