Sex-dependent changes in AMPAR expression and Na, K-ATPase activity in the cerebellum and hippocampus of α-Klotho-Hypomorphic mice.

Geovana Rosa Oliveira Dos Santos, Marina Minto Cararo-Lopes, Isabela Ribeiro Possebom, Larissa de Sá Lima, Cristoforo Scavone, Elisa Mitiko Kawamoto

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-900, São Paulo, SP, Brazil.Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-900, São Paulo, SP, Brazil. · pubmed

Paper

Abstract

Aging is characterized by a functional decline in several physiological systems. α-Klotho-hypomorphic mice (Kl

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Research summary

The paper investigates sex-dependent changes in AMPAR expression and Na, K-ATPase activity in the context of α-Klotho-hypomorphic mice, which are relevant to understanding mechanisms of aging. However, while it contributes to the knowledge of physiological changes associated with aging, it does not directly address root causes of aging or lifespan extension, limiting its overall impact.

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