V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging.
Abstract
Declines in lysosomal acidification and function with aging are observed in organisms ranging from yeast to humans. V-ATPases play a central role in organelle acidification and V- ATPase activity is regulated by reversible disassembly in many different settings. Using the yeast
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Research summary
The paper addresses the role of V-ATPase disassembly in lysosomal dysfunction during replicative aging in yeast, which is relevant to understanding the mechanisms of aging and potential interventions. While it contributes to the knowledge of lysosomal function and aging, the findings appear to be more of a solid research advance rather than a groundbreaking discovery that could significantly change the field.
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