Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism.

Tongpeng Yue, Yinping Dong, Qidong Huo, Wenxuan Li, Xinyue Wang, Shiyi Zhang, Huirong Fan, Xin Wu, Xin He, Yu Zhao, Deguan Li

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China. · pubmed

Paper

Abstract

The intestine, frequently subjected to pelvic or abdominal radiotherapy, is particularly vulnerable to delayed effects of acute radiation exposure (DEARE) owing to its high radiation sensitivity. Radiation-induced intestinal senescence, a result of DEARE, profoundly affects the well-being and quality of life of radiotherapy patients. However, targeted pharmaceutical interventions for radiation-induced senescence are currently scarce. Our findings showcase that nicotinamide riboside(NR) effectively alleviates radiation-induced intestinal senescence, offering crucial implications for utilizing NR as a pharmacological agent to combat intestinal DEARE.

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Research summary

Nicotinamide riboside alleviates radiation-induced intestinal senescence by reducing oxidative damage and regulating intestinal metabolism. The paper is relevant as it explores a potential intervention (nicotinamide riboside) that targets a mechanism (intestinal senescence) associated with aging and its detrimental effects, rather than merely addressing symptoms.

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