The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway.

Shao Zhuang Ma, Shi Dong, Zong Yuan Zhou, Xin Ye Ji, Yan Yuan Zhang, Xiao Qin Wang, Bo Zhang

Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, PR China; Key Laboratory of Xinjiang Phytomedicine Resources and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, 832002, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Cordyceps cicadae (C.cicadae), named "Chan Hua", an anamorph of Isaria cicadae Miquel, is an entomogenous complex formed by fungi parasitizing on the larvae of cicadas and belongs to the Claviciptaceae family and the genus Codyceps, which traditionally holds a significant place in Chinese ethnopharmacology, specifically for eye clarity and as a remedy for age-related ocular conditions. The underlying mechanisms contributing to its eyesight enhancement and potential effectiveness against Age-related macular degeneration (AMD) remain unexplored.

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Research summary

The paper investigates the protective effects of Cordyceps cicadae against age-related macular degeneration (AMD), which is a condition associated with aging. While it addresses a specific age-related disease, the focus is more on treatment rather than addressing the root causes of aging itself. The findings may contribute to understanding potential interventions for AMD, but they do not significantly advance the broader field of longevity research or lifespan extension. Thus, the impact is rated as solid but limited.

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