Alpha-ketoglutarate ameliorates age-related and surgery induced temporomandibular joint osteoarthritis via regulating IKK/NF-κB signaling.

Xiaoping Ye, Xinping Li, Jin Qiu, Yiwen Kuang, Bingqiang Hua, Xianwen Liu

Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China. · pubmed

Paper

Abstract

Recent studies have shed light on the important role of aging in the pathogenesis of joint degenerative diseases and the anti-aging effect of alpha-ketoglutarate (αKG). However, whether αKG has any effect on temporomandibular joint osteoarthritis (TMJOA) is unknown. Here, we demonstrate that αKG administration improves condylar cartilage health of middle-aged/aged mice, and ameliorates pathological changes in a rat model of partial discectomy (PDE) induced TMJOA. In vitro, αKG reverses IL-1β-induced/H

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Research summary

The paper investigates the effects of alpha-ketoglutarate on temporomandibular joint osteoarthritis, which is related to age-related degenerative diseases. However, it primarily focuses on symptomatic treatment rather than addressing the root causes of aging or lifespan extension. While the findings may contribute to understanding joint health in the context of aging, the overall impact on the field of longevity research is limited.

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