Perillaldehyde alleviates polyQ-induced neurodegeneration through the induction of autophagy and mitochondrial UPR in Caenorhabditis elegans.
Abstract
Huntington's disease (HD) is a fatal neurodegenerative disease associated with autophagy disorder and mitochondrial dysfunction. Here, we identified therapeutic potential of perillaldehyde (PAE), a monoterpene compound obtained from Perilla frutescens (L.) Britt., in the Caenorhabditis elegans (C. elegans) model of HD, which included lifespan extension, healthspan improvement, decrease in polyglutamine (polyQ) aggregation, and preservation of mitochondrial network. Further analyses indicated that PAE was able to induce autophagy and mitochondrial unfolded protein reaction (UPR
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Research summary
The paper investigates the therapeutic potential of perillaldehyde in a model of Huntington's disease, focusing on mechanisms such as autophagy and mitochondrial function, which are relevant to aging and neurodegeneration. While it contributes to understanding potential interventions for age-related diseases, the findings are more incremental rather than groundbreaking, thus receiving a moderate impact score.
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