LPS-induced senescence of macrophages aggravates calcification and senescence of vascular smooth muscle cells via IFITM3.

Ya-Ping Fang, Xin Yang, Ying Zhang, Xiao-Dong Zhu, Xiao-Xu Wang, Yan Liu, Wen Shi, Jia-Yi Huang, Yu Zhao, Xiao-Liang Zhang

Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China.Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China. · pubmed

Paper

Abstract

Cellular senescence, macrophages infiltration, and vascular smooth muscle cells (VSMCs) osteogenic transdifferentiation participate in the pathophysiology of vascular calcification in chronic kidney disease (CKD). Senescent macrophages are involved in the regulation of inflammation in pathological diseases. In addition, senescent cells spread senescence to neighboring cells via Interferon-induced transmembrane protein3 (IFITM3). However, the role of senescent macrophages and IFITM3 in VSMCs calcification remains unexplored.

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Research summary

The paper explores the role of senescent macrophages and their influence on vascular smooth muscle cell calcification, which is pertinent to the mechanisms of aging and age-related diseases. However, while it addresses cellular senescence, the focus on vascular calcification in chronic kidney disease suggests a more symptom-oriented approach rather than targeting the root causes of aging. Thus, while it contributes to the understanding of aging-related processes, its impact is limited and more incremental than groundbreaking.

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