Prohibitins, Phb1 and Phb2, function as Atg8 receptors to support yeast mitophagy and also play a negative regulatory role in Atg32 processing.

Diana García-Chávez, Eunice Domínguez-Martín, Laura Kawasaki, Laura Ongay-Larios, Hilario Ruelas-Ramírez, Ariann E Mendoza-Martinez, Juan P Pardo, Soledad Funes, Roberto Coria

Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Mexico City, México.Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Mexico City, México. · pubmed

Paper

Abstract

The prohibitins Phb1 and Phb2 assemble at the mitochondrial inner membrane to form a multi-dimeric complex. These scaffold proteins are highly conserved in eukaryotic cells, from yeast to mammals, and have been implicated in a variety of mitochondrial functions including aging, proliferation, and degenerative and metabolic diseases. In mammals, PHB2 regulates PINK1-PRKN mediated mitophagy by interacting with lipidated MAP1LC3B/LC3B. Despite their high conservation, prohibitins have not been linked to mitophagy in budding yeasts. In this study, we demonstrate that both Phb1 and Phb2 are required to sustain mitophagy in

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Research summary

The paper investigates the role of prohibitins in mitophagy, which is a process linked to mitochondrial function and cellular health, both of which are important in the context of aging and longevity. While the findings contribute to our understanding of mitophagy in yeast, the implications for aging and lifespan extension are still limited, making it a solid but not groundbreaking contribution to the field.

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