FOXO-regulated DEAF1 controls muscle regeneration through autophagy.

Kah Yong Goh, Wen Xing Lee, Sze Mun Choy, Gopal Krishnan Priyadarshini, Kenon Chua, Qian Hui Tan, Shin Yi Low, Hui San Chin, Chee Seng Wong, Shu-Yi Huang, Nai Yang Fu, Jun Nishiyama, Nathan Harmston, Hong-Wen Tang

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore. · pubmed

Paper

Abstract

The commonality between various muscle diseases is the loss of muscle mass, function, and regeneration, which severely restricts mobility and impairs the quality of life. With muscle stem cells (MuSCs) playing a key role in facilitating muscle repair, targeting regulators of muscle regeneration has been shown to be a promising therapeutic approach to repair muscles. However, the underlying molecular mechanisms driving muscle regeneration are complex and poorly understood. Here, we identified a new regulator of muscle regeneration, Deaf1 (Deformed epidermal autoregulatory factor-1) - a transcriptional factor downstream of foxo signaling. We showed that

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper identifies a new regulator of muscle regeneration, which is relevant to longevity research as muscle mass and function are critical for maintaining mobility and quality of life in aging populations. However, while the findings contribute to understanding muscle regeneration mechanisms, they do not directly address the root causes of aging or lifespan extension, limiting their overall impact.

Author of this paper? Send a correction.