The Influence of Aging on the Unfolded Protein Response in Human Skeletal Muscle at Rest and after Acute Exercise.
Abstract
The unfolded protein response (UPR) is a proteostatic process that is activated in response to endoplasmic reticulum stress. It is currently unclear how aging influences the chronic and adaptive UPR in human skeletal muscle. Here we determined the effect of aging on UPR activation at rest, in response to exercise, and the associations with muscle function.
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Research summary
The paper investigates the influence of aging on the unfolded protein response (UPR) in human skeletal muscle, which is relevant to understanding the biological mechanisms of aging and how they may affect muscle function. However, while it contributes to the field of aging research, the findings appear to be more incremental rather than groundbreaking, thus limiting its overall impact.
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