Study on the anti-skin aging effect and mechanism of Sijunzi Tang based on network pharmacology and experimental validation.

Hui Ke, Xingjiang Zhang, Shuang Liang, Chengyue Zhou, Yunwei Hu, Qing Huang, Jianxin Wu

Skin Health and Cosmetic Development & Evaluation Laboratory, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China.Skin Health and Cosmetic Development & Evaluation Laboratory, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China. · pubmed

Paper

Abstract

Si Jun Zi Tang (SJZT) is a famous traditional Chinese medicine formula composing of 4 herbal medicines (Ginseng Radix et Rhizoma, Atractylodis macrocephalae Rhizoma, Poria, and Glycyrrhizae Radix et Rhizoma) with tonifying spleen and anti-aging effects. It is also known that SJZT can be used to tone, nourish the skin and accelerate wound healing. However, due to the complexity of the formulation, the anti-aging especially anti-skin aging mechanisms as well as the key components of SJZT have not been fully investigated. Therefore, further in vitro and in vivo experimental studies are particularly needed to investigate the anti-skin ageing efficacy of SJZT.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the anti-skin aging effects of a traditional Chinese medicine formula, which aligns with longevity research by addressing skin aging mechanisms. However, the focus is primarily on a specific formulation rather than broader mechanisms of aging or lifespan extension. The findings may contribute to the understanding of skin aging but are unlikely to have a significant impact on the overall field of longevity research.

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