MicroRNA-361-5p Alleviates Leydig Cell Apoptosis and Promotes Cell Growth by Targeting PIAS1 in Late-Onset Hypogonadism.

Xunrong Zhou, Chunsheng Ben, Dong Wu, Anle Xia, Ping'an Chang, Bin He, Ninghan Feng, Cheng Wu

Medical College of Nantong University, 9 Qiangyuan Road, Nantong, 226001, China.Medical College of Nantong University, 9 Qiangyuan Road, Nantong, 226001, China. · pubmed

Paper

Abstract

Late-onset hypogonadism (LOH) is an age-related syndrome characterized by deficiency of serum testosterone produced by Leydig cells. Previous evidence suggested that microRNA (miR)-361-3p can serve as a promising biomarker for LOH. Nonetheless, its detailed function and molecular mechanism in LOH remain unclarified. The 24-month-old male mice were selected as an animal LOH model, and mouse Leydig cell line TM3 was stimulated with H

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Research summary

MicroRNA-361-5p alleviates Leydig cell apoptosis and promotes cell growth by targeting PIAS1 in late-onset hypogonadism. The study addresses a mechanism related to Leydig cell function and testosterone production, which are critical factors in age-related hormonal decline.

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