Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses.
Abstract
Previous studies on age-related changes in cortical and hippocampal morphology were not designed or able to reveal the complex spatial patterns of changes across the lifespan. To this end, the current study examined these changes in a decade-by-decade manner by comparing consecutive age decades at the vertex-wise level. Additionally, the lifespan trajectories of cortical/hippocampal mean thickness and total surface area were modeled and plotted out to provide an overview of their age-related changes. Using two lifespan datasets (N
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Research summary
The paper investigates age-related changes in cortical and hippocampal morphology, which are relevant to understanding the biological processes of aging. However, it primarily focuses on descriptive analyses of structural changes rather than addressing root causes of aging or proposing interventions for lifespan extension. Thus, while it contributes to the field of aging research, its impact is limited and more incremental than transformative.
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