Relationship between skeletal mitochondrial function and digital markers of free-living physical activity in older adults.

Amal A Wanigatunga, Fangyu Liu, Ryan J Dougherty, Karen Bandeen Roche, Jacek K Urbanek, Marta Zampino, Eleanor M Simonsick, Qu Tian, Jennifer A Schrack, Luigi Ferrucci

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. [email protected] of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. [email protected]. · pubmed

Paper

Abstract

This study examined the association between in vivo skeletal mitochondrial function and digital free-living physical activity patterns-a measure that summarizes biological, phenotypic, functional, and environmental effects on mobility. Among 459 participants (mean age 68 years; 55% women) in the Baltimore Longitudinal Study of Aging, mitochondrial function was quantified as skeletal muscle oxidative capacity via post-exercise phosphocreatine recovery rate (τ

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Research summary

The study investigates the relationship between skeletal mitochondrial function and physical activity in older adults, which is pertinent to understanding the biological mechanisms underlying aging and mobility. However, while it contributes to the knowledge of mitochondrial function in the context of aging, it does not address root causes of aging or lifespan extension directly. Thus, its impact is solid but limited.

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