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RESEARCH PAPER / 2024-05-21

Age Is Just a Number for Older Kidney Transplant Patients.

Evelien E Quint, Robert A Pol, Dorry L Segev, Mara A McAdams-DeMarco

Division of Transplant Surgery, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.Division of Transplant Surgery, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands. · pubmed

Abstract

The rise in the mean age of the global population has led to an increase in older kidney transplant (KT) patients. This demographic shift, coupled with the ongoing organ shortage, requires a nuanced understanding of which older adults are most suitable for KT. Recognizing the increased heterogeneity among older adults and the limitations of solely relying on chronological age, there is a need to explore alternative aging metrics beyond chronological age. In this review, we discuss the impact of older age on access to KT and postoperative outcomes. Emphasizing the need for a comprehensive evaluation that extends beyond chronological age, we explore alternative aging metrics such as frailty, sarcopenia, and cognitive function, underscoring their potential role in enhancing the KT evaluation process. Most importantly, we aim to contribute to the ongoing discourse, fostering an optimized approach to KT for the rapidly growing population of older adults.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the evaluation of older kidney transplant patients, focusing on alternative aging metrics rather than solely chronological age. While it contributes to the understanding of aging in the context of organ transplantation, it does not directly tackle the root causes of aging or lifespan extension. Its impact is solid but limited, as it primarily discusses existing metrics and their application rather than presenting novel insights or breakthroughs in longevity research.

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