High-fat diet induces sarcopenic obesity in natural aging rats through the gut-trimethylamine N-oxide-muscle axis.

Xiaoxing Mo, Ruijie Cheng, Lihui Shen, Yunhong Sun, Pei Wang, Guanhua Jiang, Lin Wen, Xiaoqin Li, Xiaobo Peng, Yuxiao Liao, Ruikun He, Hong Yan, Liegang Liu

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China. · pubmed

Paper

Abstract

The lack of suitable animal models for sarcopenic obesity (SO) limits in-depth research into the disease. Emerging studies have demonstrated that gut dysbiosis is involved in the development of SO. As the importance of microbial metabolites is starting to unveil, it is necessary to comprehend the specific metabolites associated with gut microbiota and SO.

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Research summary

The paper claims that a high-fat diet induces sarcopenic obesity in aging rats through the gut-trimethylamine N-oxide-muscle axis. This research is relevant as it explores the underlying mechanisms of sarcopenic obesity, which is a significant age-related condition that affects longevity and overall health in aging populations.

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