Advanced Glycation End Products and Health: A Systematic Review.
Abstract
Advanced glycation end products (AGEs) have garnered significant attention due to their association with chronic diseases and the aging process. The prevalence of geriatric diseases among young individuals has witnessed a notable surge in recent years, potentially attributed to the accelerated pace of modern life. The accumulation of AGEs is primarily attributed to their inherent difficulty in metabolism, which makes them promising biomarkers for chronic disease detection. This review aims to provide a comprehensive overview of the recent advancements and findings in AGE research. The discussion is divided into two main sections: endogenous AGEs (formed within the body) and exogenous AGEs (derived from external sources). Various aspects of AGEs are subsequently summarized, including their production pathways, pathogenic mechanisms, and detection methods. Moreover, this review delves into the future research prospects concerning AGEs. Overall, this comprehensive review underscores the importance of AGEs in the detection of chronic diseases and provides a thorough understanding of their significance. It emphasizes the necessity for further research endeavors to deepen our comprehension of AGEs and their implications for human health.
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Research summary
The paper discusses advanced glycation end products (AGEs) and their association with chronic diseases, which is relevant to aging and age-related health issues. However, it primarily focuses on the detection and understanding of AGEs rather than addressing the root causes of aging or proposing solutions for lifespan extension. The findings contribute to the existing knowledge but do not present significant advancements that would have a major impact on the field of longevity research.
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