Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan.
Abstract
Aging is associated with a global decline in stem cell function. To date, several strategies have been proposed to rejuvenate aged stem cells: most of these result in functional improvement of the tissue where the stem cells reside, but the impact on the lifespan of the whole organism has been less clearly established. Here, we review some of the most recent work dealing with interventions that improve the regenerative capacity of aged somatic stem cells in mammals and that might have important translational possibilities. Overall, we underscore that somatic stem cell rejuvenation represents a strategy to improve tissue homeostasis upon aging and present some recent approaches with the potential to affect health span and lifespan of the whole organism.
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Research summary
The paper discusses strategies to rejuvenate aged stem cells, which is directly related to improving health span and potentially lifespan by addressing the decline in stem cell function associated with aging. While the review highlights important interventions and their translational possibilities, it primarily summarizes existing work rather than presenting novel findings or groundbreaking insights. Thus, it contributes solidly to the field but lacks the depth or novelty to be considered highly impactful.
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